Oceanic environments are one of the largest sources of bioactive molecules, due to the high
degree of biodiversity and the innumerable ecological relationships established between …

Taxane‐derived drugs are antineoplastic agents used for the treatment of highly common
malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however …

Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …

The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with
various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The …

Venomous animals on the earth have been found to be valuable resources for the
development of therapeutics. Enzymatic and non-enzymatic proteins and peptides are the …

Background and Purpose Peptides from venomous animals have long been important for
understanding pain mechanisms and for the discovery of pain treatments. Here, we …

Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …

Cisplatin is important in the treatment of various types of cancer. Although it is highly
effective, it also has severe side effects, with neurotoxicity in dorsal root ganglion (DRG) …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common cause of pain and poor
quality of life for those undergoing treatment for cancer and those surviving cancer. Many …

The aim of this research was to assess the antinociceptive activity of the transient receptor
potential (TRP) channel TRPV1, TRPM8, and TRPA1 antagonists in neurogenic, tonic, and …