The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …

Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Abstract Background Elevated oxidative stress (OxS), mitochondrial dysfunction, and
hallmarks of aging are identified as key contributors to aging, but improving/reversing these …

Humanity is battling a respiratory pandemic pneumonia named COVID-19 which has
resulted in millions of hospitalizations and deaths. COVID-19 exacerbations occur in waves …

Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

In clinical trials, biochemical markers provide useful information on the drug's mode of
action, therapeutic response and side effect monitoring and can act as surrogate endpoints …

Determinants of length of life are not well understood, and therefore increasing lifespan is a
challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial …

Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is …

One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon
units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key …

Glutathione (GSH) has special antioxidant properties due to its high intracellular
concentration, ubiquity, and high reactivity towards electrophiles of the sulfhydryl group of its …