The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Human heart failure, a leading cause of death worldwide, is a prominent example of a
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …

We have previously developed a high-throughput bioengineered human cardiac organoid
(hCO) platform, which provides functional contractile tissue with biological properties similar …

The adult mammalian heart has limited capacity for regeneration following injury, whereas
the neonatal heart can readily regenerate within a short period after birth. Neonatal heart …

The neonatal mammalian heart is capable of regeneration for a brief window of time after
birth. However, this regenerative capacity is lost within the first week of life, which coincides …

Background: A key cause of the high mortality of cardiovascular diseases is the
cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement …

Heart regeneration, a relatively new field of biology, is one of the most active and
controversial areas of biomedical research. The potential impact of successful human heart …

This paper aims to provide an important update on the recent preclinical and clinical trials
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …

Regeneration is a heroic biological process that restores tissue architecture and function in
the face of day-to-day cell loss or the aftershock of injury. Capacities and mechanisms for …