Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

Abstract Heat shock protein (HSP) 90, an important component of the molecular chaperone
network, is closely concerned with cellular signaling pathways and stress response by …

Cell death, particularly that of tubule epithelial cells, contributes critically to the
pathophysiology of kidney disease. A body of evidence accumulated over the past 15 years …

Sepsis is a systemic inflammatory response syndrome caused by infection, following with
acute injury to multiple organs. Sepsis-induced acute kidney injury (AKI) is currently …

Selenium (Se) deficiency can affect the expression of microRNA (miRNA) and induce
necroptosis, apoptosis, etc., resulting in damage to various tissues and organs. Bisphenol A …

RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in
neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS). Preclinical …

Cytokine storms are an important mechanism of sepsis. TNF-α is an important cytokine. As a
regulator of TNF superfamily receptors, RIPK1 not only serves as the basis of the scaffold …

In the past decades, apoptosis has been the most well-studied regulated cell death (RCD)
that has essential functions in tissue homeostasis throughout life. However, a novel form of …

A delicate balance between programmed cell death and proliferation of intestinal epithelial
cells (IEC) exists in the gut to maintain homeostasis. Homeostatic cell death programs such …

Historically considered a metabolically inert cellular layer separating the blood from the
underlying tissue, the endothelium is now recognized as a highly dynamic, metabolically …