Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

The spike protein of SARS-CoV-2 has been a promising target for developing vaccines and
therapeutics due to its crucial role in the viral entry process. Previously reported cryogenic …

Allosteric mechanisms are commonly employed regulatory tools used by proteins to
orchestrate complex biochemical processes and control communications in cells. The …

As the world struggles with the ongoing COVID-19 pandemic, unprecedented obstacles
have continuously been traversed as new SARS-CoV-2 variants continually emerge …

Highlights•Mutation informatics study on RBD of SARS-CoV-2 variants.•Discussion of small
molecules targeting the RBD/ACE2 interface.•Ideation to design novel inhibitors against wild …

Large-scale studies of single-cell sequencing and biological experiments have successfully
revealed expression patterns that distinguish different cell types in tissues, emphasizing the …

ACE2 is a major receptor for cellular entry of SARS‐CoV‐2. Despite advances in targeting
ACE2 to inhibit SARS‐CoV‐2 binding, strategies to flexibly and sufficiently reduce ACE2 …

Coronavirus disease 2019 (COVID-19) caused by the infection of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has become the most severe health crisis, causing …

The fusion of viral and cell membranes is one of the basic processes in the life cycles of
viruses. A number of enveloped viruses confer fusion of the viral envelope and the cell …