Health and longevity in all organisms are strongly influenced by the environment. To fully
understand how environmental factors interact with genetic and stochastic factors to …

Toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that promote
age-associated functional neuronal decline and neurodegenerative disease across species …

We have miniaturized standard culture techniques to rear arrays of isolated, individual C.
elegans throughout their lives on solid gel media. The resulting apparatus is compatible with …

Hookworms remain a major health burden in the developing world, with hundreds of millions
currently afflicted by these blood-feeding parasites. There exists a vital need for the …

The aging process has broad physiological impacts, including a significant decline in
sensory function, which threatens both physical health and quality of life. One ideal model to …

Controlling nematode-caused diseases that affect cattle and crops world-wide remains a
critical economic issue, owing to the lack of effective sustainable interventions. The …

Coordinated regulation of stress response pathways is crucial for cellular homeostasis.
However, crosstalk between the different stress pathways and the physiological significance …

Caenorhabditis elegans is an instrumental model in aging research due to its large brood
size, short lifespan, and malleable genetics. However, maintaining a synchronous nematode …

Alteration of the lipid composition of biological membranes interferes with their function and
can cause tissue damage by triggering apoptosis. Upon lipid bilayer stress, the endoplasmic …

Secretory organs are critical for organismal survival. Yet, the transcriptional regulatory
mechanisms governing their development and maintenance remain unclear for most model …