Inflammation is a most complex pathological process that gives birth to different diseases.
Different inflammatory mediators are released during an inflammation responsible for acute …

Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

The present study includes design and synthesis of new molecular hybrids of 2-
methylthiobenzimidazole linked to various anti-inflammatory pharmacophores through 2 …

Selective inhibition of both cyclooxygenase-2 (COX-2) and 15-lipooxygenase (15-LOX) may
provide good strategy for alleviation of inflammatory disorders while minimizing side effects …

In this study, the chemical compositions of the ethanolic and aqueous extracts of the leaves
of Origanum syriacum and Salvia lanigera were identified based on GC-MS spectrometric …

New pyrazolone derivatives structurally related to celecoxib and FPL 62064 were
synthesized and biologically evaluated for their inhibitory activity against cyclooxygenases …

A new series of co-drugs was designed based on hybridising the dihydropteroate synthase
(DHPS) inhibitor sulphonamide scaffold with the COX-2 inhibitor salicylamide …

A total of 19 resveratrol derivatives, including 12 imines and 7 amines, were synthesized,
among which compounds 1, 5, 6, 7′, 11′, and 13 are new compounds. The anti …

Lavendustin C, a natural-product derived anticancer lead compound, was modified at its
carboxylic group by esterification or amidation (compounds 6–10) and at its amino group by …

Eicosanoids like leukotrienes and prostaglandins that produced within the arachidonic acid
cascade are involved in the pathogenesis of pain, acute and chronic inflammatory diseases …