Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in
metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in …

Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of
external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …

More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and …

Planar polarity describes the coordinated polarisation of cells or structures in the plane of a
tissue. The patterning mechanisms that underlie planar polarity are well characterised in …