Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids
in the gastrointestinal track during normal physiological conditions as well as hepatic and …

Adrenoleukodystrophy (ALD) is a rare X‐linked disease caused by a mutation of the
peroxisomal ABCD1 gene. This review summarizes our current understanding of the …

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are
cholesterol metabolites that can signal through receptors on cells throughout the body …

This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …

Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which
has been demonstrated to have neuroprotective effects in different neurological disease …

ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of
conserved proteins from bacteria to mammals. In humans, three members of this family are …

With the acceleration of global population aging, neurodegenerative diseases (NDs) will
become the second leading cause of death in the world, which seriously threatens human …

Objective ALS is a rapidly progressive, fatal disorder caused by motor neuron degeneration,
for which there is a great unmet therapeutic need. AMX0035, a combination of sodium …

A metabolic illness known as non-alcoholic fatty liver disease (NAFLD), affects more than
one-quarter of the world's population. Bile acids (BAs), as detergents involved in lipid …