Microglia‐derived inflammatory neurotoxins play a principal role in the pathogenesis of
neurodegenerative disorders including Alzheimer's disease, Parkinson's disease …

It has been nearly a century since the early description of microglia by Rio-Hortega; since
then many more biological and pathological features of microglia have been recognized …

Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and
debilitating neurological problems that include behavioral abnormalities, motor dysfunction …

Neurodegenerative and infectious disorders including Alzheimer's and Parkinson's
diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population's …

HIV infection is associated with disturbances in brain function which reflect themselves in
HIV associated neurocognitive disorder (HAND). Neurocognitive examination is a sensitive …

Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons. We
tested the hypothesis that proteomic analysis will identify protein biomarkers that provide …

Human immunodeficiency virus type 1 (HIV-1)-associated dementia is a neuroinflammatory
brain disorder that is fueled by viral infection and immune activation of brain mononuclear …

Recent studies using mass spectrometry have discovered candidate biomarkers for
amyotrophic lateral sclerosis (ALS). However, those studies utilized small numbers of ALS …

A broad range of nanomedicines is being developed to improve drug delivery for CNS
disorders. The structure of the blood–brain barrier (BBB), the presence of efflux pumps and …

Human immunodeficiency virus encephalitis causes dementia in acquired immune
deficiency syndrome patients. Using proteomic analysis of postmortem cerebrospinal fluid …