Melioidosis

WJ Wiersinga, BJ Currie… - New England Journal of …, 2012 - Mass Medical Soc
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Laboratory diagnosis of melioidosis: past, present and future

SKP Lau, S Sridhar, CC Ho, WN Chow… - Experimental …, 2015 - journals.sagepub.com
Melioidosis is an emerging, potentially fatal disease caused by Burkholderia pseudomallei,
which requires prolonged antibiotic treatment to prevent disease relapse. However …

Horizontal gene transfer contributes to virulence and antibiotic resistance of Vibrio harveyi 345 based on complete genome sequence analysis

Y Deng, H Xu, Y Su, S Liu, L Xu, Z Guo, J Wu, C Cheng… - BMC genomics, 2019 - Springer
Background Horizontal gene transfer (HGT), which is affected by environmental pollution
and climate change, promotes genetic communication, changing bacterial pathogenicity and …

Global and regional dissemination and evolution of Burkholderia pseudomallei

C Chewapreecha, MTG Holden, M Vehkala… - Nature …, 2017 - nature.com
The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000
cases of human melioidosis per year worldwide and is also classified as a biothreat agent …

Within-Host Evolution of Staphylococcus aureus during Asymptomatic Carriage

T Golubchik, EM Batty, RR Miller, H Farr, BC Young… - PloS one, 2013 - journals.plos.org
Background Staphylococcus aureus is a major cause of healthcare associated mortality, but
like many important bacterial pathogens, it is a common constituent of the normal human …

Opera: reconstructing optimal genomic scaffolds with high-throughput paired-end sequences

S Gao, N Nagarajan, WK Sung - … 2011, Vancouver, BC, Canada, March 28 …, 2011 - Springer
Scaffolding, the problem of ordering and orienting contigs, typically using paired-end reads,
is a crucial step in the assembly of high-quality draft genomes. Even as sequencing …

Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade

CT French, IJ Toesca, TH Wu… - Proceedings of the …, 2011 - National Acad Sciences
Burkholderia pseudomallei and Burkholderia thailandensis are related pathogens that
invade a variety of cell types, replicate in the cytoplasm, and spread to nearby cells. We …

Unexpected and widespread connections between bacterial glycogen and trehalose metabolism

G Chandra, KF Chater, S Bornemann - Microbiology, 2011 - microbiologyresearch.org
Glycogen, a large α-glucan, is a ubiquitous energy storage molecule among bacteria, and its
biosynthesis by the classical GlgC-GlgA pathway and its degradation have long been well …

The Type VI secretion system spike protein VgrG5 mediates membrane fusion during intercellular spread by pseudomallei group Burkholderia species

IJ Toesca, CT French, JF Miller - Infection and immunity, 2014 - Am Soc Microbiol
Pseudomallei group Burkholderia species are facultative intracellular parasites that spread
efficiently from cell to cell by a mechanism involving the fusion of adjacent cell membranes …

A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A

A Cruz-Migoni, GM Hautbergue, PJ Artymiuk, PJ Baker… - Science, 2011 - science.org
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei,
reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that …