Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?
An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …
The molecular heterogeneity of store-operated Ca2+ entry in vascular endothelial cells: the different roles of Orai1 and TRPC1/TRPC4 channels in the transition from …
F Moccia, V Brunetti, A Perna, G Guerra… - International journal of …, 2023 - mdpi.com
Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …
[HTML][HTML] Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent …
Endothelial colony forming cells (ECFCs) represent the most suitable cellular substrate to
induce revascularization of ischemic tissues. Recently, optical excitation of the light-sensitive …
induce revascularization of ischemic tissues. Recently, optical excitation of the light-sensitive …
Intracellular Ca2+ signalling: unexpected new roles for the usual suspect
Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain …
The excitatory neurotransmitter glutamate gates post-synaptic N-methyl-d-aspartate (NMDA)
receptors (NMDARs) to mediate extracellular Ca 2+ entry and stimulate neuronal nitric oxide …
receptors (NMDARs) to mediate extracellular Ca 2+ entry and stimulate neuronal nitric oxide …
GABAA and GABAB Receptors Mediate GABA-Induced Intracellular Ca2+ Signals in Human Brain Microvascular Endothelial Cells
Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …
Targeting endolysosomal two-pore channels to treat cardiovascular disorders in the novel COronaVIrus Disease 2019
Emerging evidence hints in favor of a life-threatening link between severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2) and the cardiovascular system. SARS-CoV-2 …
syndrome coronavirus type 2 (SARS-CoV-2) and the cardiovascular system. SARS-CoV-2 …
Cracking the Endothelial Calcium (Ca2+) Code: A Matter of Timing and Spacing
A monolayer of endothelial cells lines the innermost surface of all blood vessels, thereby
coming into close contact with every region of the body and perceiving signals deriving from …
coming into close contact with every region of the body and perceiving signals deriving from …
Activation of endo-lysosomal two-pore channels by NAADP and PI (3, 5) P2. Five things to know.
Two-pore channels are ancient members of the voltage-gated ion channel superfamily that
are expressed predominantly on acidic organelles such as endosomes and lysosomes …
are expressed predominantly on acidic organelles such as endosomes and lysosomes …
The human amniotic fluid stem cell secretome triggers intracellular Ca2+ oscillations, NF‐κB nuclear translocation and tube formation in human endothelial colony …
Second trimester foetal human amniotic fluid‐derived stem cells (hAFS) have been shown to
possess remarkable cardioprotective paracrine potential in different preclinical models of …
possess remarkable cardioprotective paracrine potential in different preclinical models of …