The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

It has been hypothesized that individually-rare hidden structural variants (SVs) could
account for a significant fraction of variation in complex traits. Here we identified more than …

The insulin receptor gene encodes an evolutionarily conserved signaling protein with a wide
spectrum of functions in metazoan development. The insulin signaling pathway plays key …

Key discoveries in Drosophila have shaped our understanding of cellular “enhancers.” With
a special focus on the fly, this chapter surveys properties of these adaptable cis-regulatory …

One of the most important questions in regenerative biology is to unveil how and when
genes change expression and trigger regeneration programs. The resetting of gene …

Context Altered expression of the insulin receptor (IR) in adipose tissue (AT) could
contribute to gestational diabetes mellitus (GDM) etiopathogenesis. Transcriptional …

Cis-regulatory elements control transcription levels, temporal dynamics, and cell-cell
variation or transcriptional noise. However, the combination of regulatory features that …

The insulin signalling pathway plays a crucial role in regulating the metabolism of sugars,
fats and proteins in cells, thereby affecting the growth, metabolism, reproduction and ageing …

Diabetes mellitus (DM) has been associated with cognitive complications in the brain
resulting from acute and chronic metabolic disturbances happening peripherally and …