[HTML][HTML] Therapeutic perspective of vitamin C and its derivatives
l-Ascorbic acid (ASA), vitamin C, is a ubiquitous carbohydrate-like compound that has an
essential role in a number of cellular processes, such as collagen synthesis, cellular …
essential role in a number of cellular processes, such as collagen synthesis, cellular …
[HTML][HTML] Understanding the therapeutic potential of ascorbic acid in the battle to overcome cancer
Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various
developments to prevent and treat cancer, the side effects of anticancer drugs remain a …
developments to prevent and treat cancer, the side effects of anticancer drugs remain a …
Antitumor and antiviral activities of 4-substituted 1, 2, 3-triazolyl-2, 3-dibenzyl-L-ascorbic acid derivatives
Abstract Two series of 6-(1, 2, 3-triazolyl)-2, 3-dibenzyl-l-ascorbic acid derivatives with the
hydroxyethylene (8a− 8u) and ethylidene linkers (10c− 10p) were synthesized and …
hydroxyethylene (8a− 8u) and ethylidene linkers (10c− 10p) were synthesized and …
The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: Synthesis, cytostatic, and antiviral activity evaluations
The novel C-5 substituted uracil derivatives of l-ascorbic acid were synthesized by coupling
of 5-iodouracil-4, 5-didehydro-5, 6-dideoxy-l-ascorbic acid with unsaturated stannanes …
of 5-iodouracil-4, 5-didehydro-5, 6-dideoxy-l-ascorbic acid with unsaturated stannanes …
[HTML][HTML] [18F] KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates
Over production of reactive oxygen species (ROS) caused by altered redox regulation of
signaling pathways is common in many types of cancers. While PET imaging is recognized …
signaling pathways is common in many types of cancers. While PET imaging is recognized …
Synthesis and Antiviral and Cytostatic Evaluations of the New C-5 Substituted Pyrimidine and Furo[2,3-d]pyrimidine 4',5'-Didehydro-l-ascorbic Acid Derivatives
T Gazivoda, M Šokčević, M Kralj… - Journal of medicinal …, 2007 - ACS Publications
The novel C-5 alkynyl substituted pyrimidine (1− 11) and furo [2, 3-d] pyrimidine derivatives
(12− 22) of l-ascorbic acid were synthesized by coupling of 5-iodouracil-4 ', 5 '-didehydro-5 ' …
(12− 22) of l-ascorbic acid were synthesized by coupling of 5-iodouracil-4 ', 5 '-didehydro-5 ' …
[HTML][HTML] Continuous flow-ultrasonic synergy in click reactions for the synthesis of novel 1, 2, 3-triazolyl appended 4, 5-unsaturated L-ascorbic acid derivatives
A combination of flow chemistry and batch-based synthetic procedures has been
successfully applied to the assembly of novel 4, 5-unsaturated L-ascorbic acid series 6a–6n …
successfully applied to the assembly of novel 4, 5-unsaturated L-ascorbic acid series 6a–6n …
[PDF][PDF] Antioxidant and radical scavenging activities of ascorbic acid derivatives conjugated with organogermanium
C Oh, M Li, EH Kim, JS Park, JC Lee… - Bulletin of the Korean …, 2010 - scholarworks.bwise.kr
L-Ascorbic acid, also known as vitamin C, is one of the potent naturally-occurring
antioxidants in a biological system. 1 Although ascorbic acid has a range of physiological …
antioxidants in a biological system. 1 Although ascorbic acid has a range of physiological …
[HTML][HTML] Initial biological evaluations of 18F-KS1, a novel ascorbate derivative to image oxidative stress in cancer
KK Solingapuram Sai, N Bashetti, X Chen, S Norman… - EJNMMI research, 2019 - Springer
Background Reactive oxygen species (ROS)-induced oxidative stress damages many
cellular components such as fatty acids, DNA, and proteins. This damage is implicated in …
cellular components such as fatty acids, DNA, and proteins. This damage is implicated in …
Green Solvent-Free Synthesis of New N-Heterocycle-L-Ascorbic Acid Hybrids and Their Antiproliferative Evaluation
Aim: The authors' aim was to improve the application of copper-catalyzed azide-alkyne
cycloaddition in the synthesis of hybrids containing biologically significant nucleobases and …
cycloaddition in the synthesis of hybrids containing biologically significant nucleobases and …