Multimodal fusion in neuroimaging combines data from multiple imaging modalities to
overcome the fundamental limitations of individual modalities. Neuroimaging fusion can …

The neurodevelopmental and dopamine hypotheses are leading theories of the
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Abstract The complement component 4 (C4) gene is linked to schizophrenia and synaptic
refinement. In humans, greater expression of C4A in the brain is associated with an …

Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

The idea that a longer duration of untreated psychosis (DUP) leads to poorer outcomes has
contributed to extensive changes in mental health services worldwide and has attracted …

The involvement of the gut microbiota and the metabolites of colon-residing bacteria in brain
disease pathogenesis has been covered in a growing number of studies, but comparative …