Hydrogel microenvironments for cancer spheroid growth and drug screening
Y Li, E Kumacheva - Science advances, 2018 - science.org
Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …
Squish and squeeze—the nucleus as a physical barrier during migration in confined environments
From embryonic development to cancer metastasis, cell migration plays a central role in
health and disease. It is increasingly becoming apparent that cells migrating in three …
health and disease. It is increasingly becoming apparent that cells migrating in three …
The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks
The behavior of cancer cells is strongly influenced by the properties of extracellular
microenvironments, including topology, mechanics and composition. As topological and …
microenvironments, including topology, mechanics and composition. As topological and …
Role of the tumor microenvironment in cancer hallmarks and targeted therapy
R Naser, I Fakhoury, A El-Fouani… - International …, 2022 - spandidos-publications.com
Genetic alterations drive tumor onset and progression. However, the cross-talk between
tumor cells and the benign components of the surrounding stroma can also promote the …
tumor cells and the benign components of the surrounding stroma can also promote the …
Engineering bioprintable alginate/gelatin composite hydrogels with tunable mechanical and cell adhesive properties to modulate tumor spheroid growth kinetics
T Jiang, JG Munguia-Lopez, K Gu, MM Bavoux… - …, 2019 - iopscience.iop.org
Tunable bioprinting materials are capable of creating a broad spectrum of physiological
mimicking 3D models enabling in vitro studies that more accurately resemble in vivo …
mimicking 3D models enabling in vitro studies that more accurately resemble in vivo …
Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells
Extracellular matrix stiffening of breast tissues has been clinically correlated with malignant
transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase …
transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase …
Biomimetic tumor microenvironments based on collagen matrices
The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …
providing structural and mechanical support to cells and tissues, and regulating multiple cell …
Self-assembly of mesoscale collagen architectures and applications in 3D cell migration
Abstract 3D in vitro tumor models have recently been investigated as they can recapitulate
key features in the tumor microenvironment. Reconstruction of a biomimetic scaffold is …
key features in the tumor microenvironment. Reconstruction of a biomimetic scaffold is …
[HTML][HTML] Biophysical cues of in vitro biomaterials-based artificial extracellular matrix guide cancer cell plasticity
RZ Tang, XQ Liu - Materials Today Bio, 2023 - Elsevier
Clinical evidence supports a role for the extracellular matrix (ECM) in cancer plasticity
across multiple tumor types. The lack of in vitro models that represent the native ECMs is a …
across multiple tumor types. The lack of in vitro models that represent the native ECMs is a …
3D collagen fibrillar microstructure guides pancreatic cancer cell phenotype and serves as a critical design parameter for phenotypic models of EMT
TJ Puls, X Tan, CF Whittington, SL Voytik-Harbin - PloS one, 2017 - journals.plos.org
Pancreatic cancer, one of the deadliest cancers, is characterized by high rates of metastasis
and intense desmoplasia, both of which are associated with changes in fibrillar type I …
and intense desmoplasia, both of which are associated with changes in fibrillar type I …