Natural‐product sugar biosynthesis and enzymatic glycodiversification

CJ Thibodeaux, CE Melançon III… - Angewandte Chemie …, 2008 - Wiley Online Library
Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Modification of post-PKS tailoring steps through combinatorial biosynthesis

U Rix, C Fischer, LL Remsing, J Rohr - Natural product reports, 2002 - pubs.rsc.org
Covering: 1985–2002. This review covers the highlights of combinatorial biosynthesis
applied on post-polyketide synthase modifying enzymes, such as oxygenases …

Altering the glycosylation pattern of bioactive compounds

C Méndez, JA Salas - TRENDS in Biotechnology, 2001 - cell.com
Many bioactive natural products are glycosylated compounds in which the sugars are
important or essential for biological activity. The isolation of several sugar biosynthesis gene …

Formation of unusual sugars: mechanistic studies and biosynthetic applications

XM He, H Liu - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract Carbohydrates are highly abundant biomolecules found extensively in nature.
Besides playing important roles in energy storage and supply, they often serve as essential …

Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars

H Zhang, JA White-Phillip, CE Melançon… - Journal of the …, 2007 - ACS Publications
The antibiotic kijanimicin produced by the actinomycete Actinomadura kijaniata has a broad
spectrum of bioactivities as well as a number of interesting biosynthetic features. To …

Type I polyketide biosynthesis in bacteria (Part A—erythromycin biosynthesis)

BJ Rawlings - Natural product reports, 2001 - pubs.rsc.org
This two-part review summarises the literature for the biosynthesis of Type I polyketide
biosynthesis in bacteria from the end of 1994 through to mid-2000, and should be read in …

Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs

N Menéndez, M Nur-e-Alam, AF Braña, J Rohr… - Chemistry & biology, 2004 - cell.com
The biosynthetic gene cluster of the aureolic acid type antitumor drug chromomycin A 3 from
S. griseus subsp. griseus has been identified and characterized. It spans 43 kb and contains …

Type I polyketide biosynthesis in bacteria (Part B)

BJ Rawlings - Natural product reports, 2001 - pubs.rsc.org
This is the second part (Part B) of a review that summarises the literature for Type I
polyketide biosynthesis in bacteria from the end of 1994 through to mid-2000, and should be …

Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of TDP-l-epivancosamine in chloroeremomycin biosynthesis

H Chen, MG Thomas, BK Hubbard… - Proceedings of the …, 2000 - National Acad Sciences
The 2, 3, 6-trideoxysugar l-epivancosamine is the terminal sugar added to the aglycone
scaffold in chloroeremomycin, a member of the vancomycin family of glycopeptide …

Novel enzymatic mechanisms in carbohydrate metabolism

X He, G Agnihotri, H Liu - Chemical reviews, 2000 - ACS Publications
Carbohydrates form the most abundant group of natural products and are found in all
classes of living organisms. 1-8 They serve as a direct link between the energy of the sun …