Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy. Most
TPD technologies use the ubiquitin–proteasome system, and are therefore limited to …

The possibility that proteinuria may accelerate kidney disease progression to end-stage
renal failure has received support from the results of increasing numbers of experimental …

Albumin is the most abundant plasmaprotein serving multiple functions as a carrier of
metabolites, hormones, vitamins, and drugs, as an acid/base buffer, as antioxidant and by …

A growing body of evidence indicates that the renal proximal tubular epithelial cell (PTEC)
plays an important role in the pathogenesis of diabetic nephropathy (DN). Microalbuminuria …

OBJECTIVE—Glomerular mesangial expansion and podocyte loss are important early
features of diabetic nephropathy, whereas tubulointerstitial injury and fibrosis are critical for …

Overcome the toughest clinical challenges in nephrology with the new 9th edition of
Brenner/Rector's The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M …

Background Tubulointerstitial fibrosis (TIF) plays an important role in the progression of
diabetic kidney disease (DKD). Forkhead box O1 (FoxO1) is involved in the regulation of …

Chronic proteinuric renal diseases, independent from the type of the initial insult, have in
common a loss of selectivity of the glomerular barrier to protein filtration. Glomerular …