[HTML][HTML] Renal tubule injury: a driving force toward chronic kidney disease
Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …
Oxidant mechanisms in renal injury and disease
BB Ratliff, W Abdulmahdi, R Pawar… - Antioxidants & redox …, 2016 - liebertpub.com
Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …
Bifunctional small molecules that mediate the degradation of extracellular proteins
Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy. Most
TPD technologies use the ubiquitin–proteasome system, and are therefore limited to …
TPD technologies use the ubiquitin–proteasome system, and are therefore limited to …
How does proteinuria cause progressive renal damage?
The possibility that proteinuria may accelerate kidney disease progression to end-stage
renal failure has received support from the results of increasing numbers of experimental …
renal failure has received support from the results of increasing numbers of experimental …
[HTML][HTML] Renal albumin absorption in physiology and pathology
H Birn, EI Christensen - Kidney international, 2006 - Elsevier
Albumin is the most abundant plasmaprotein serving multiple functions as a carrier of
metabolites, hormones, vitamins, and drugs, as an acid/base buffer, as antioxidant and by …
metabolites, hormones, vitamins, and drugs, as an acid/base buffer, as antioxidant and by …
The pathogenic role of the renal proximal tubular cell in diabetic nephropathy
SCW Tang, KN Lai - Nephrology Dialysis Transplantation, 2012 - academic.oup.com
A growing body of evidence indicates that the renal proximal tubular epithelial cell (PTEC)
plays an important role in the pathogenesis of diabetic nephropathy (DN). Microalbuminuria …
plays an important role in the pathogenesis of diabetic nephropathy (DN). Microalbuminuria …
Enhanced expression of Janus kinase–signal transducer and activator of transcription pathway members in human diabetic nephropathy
CC Berthier, H Zhang, ML Schin, A Henger… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE—Glomerular mesangial expansion and podocyte loss are important early
features of diabetic nephropathy, whereas tubulointerstitial injury and fibrosis are critical for …
features of diabetic nephropathy, whereas tubulointerstitial injury and fibrosis are critical for …
[图书][B] Brenner and Rector's The Kidney E-Book
Overcome the toughest clinical challenges in nephrology with the new 9th edition of
Brenner/Rector's The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M …
Brenner/Rector's The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M …
FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease
F Huang, Q Wang, F Guo, Y Zhao, L Ji, T An, Y Song… - …, 2019 - thelancet.com
Background Tubulointerstitial fibrosis (TIF) plays an important role in the progression of
diabetic kidney disease (DKD). Forkhead box O1 (FoxO1) is involved in the regulation of …
diabetic kidney disease (DKD). Forkhead box O1 (FoxO1) is involved in the regulation of …
Progression of renal injury toward interstitial inflammation and glomerular sclerosis is dependent on abnormal protein filtration
Chronic proteinuric renal diseases, independent from the type of the initial insult, have in
common a loss of selectivity of the glomerular barrier to protein filtration. Glomerular …
common a loss of selectivity of the glomerular barrier to protein filtration. Glomerular …