Abstract Information in proteins flows from sequence to structure to function, with each step
causally driven by the preceding one. Protein design is founded on inverting this process …

Genome editing has been a transformative force in the life sciences and human medicine,
offering unprecedented opportunities to dissect complex biological processes and treat the …

Protein design and engineering are evolving at an unprecedented pace leveraging the
advances in deep learning. Current models nonetheless cannot natively consider non …

Designing sequences for specific protein backbones is a key step in creating new functional
proteins. Here, we introduce GeoSeqBuilder, a deep learning framework that integrates …

Native prokaryotic promoters share common sequence patterns, but are species dependent.
For understudied species with limited data, it is challenging to predict the strength of existing …

Intrinsically disordered proteins have dynamic structures through which they play key
biological roles. The elucidation of their conformational ensembles is a challenging problem …

Inteins are proteins that excise themselves out of host proteins and ligate the flanking
polypeptides in an auto‐catalytic process called protein splicing. In nature, inteins are either …

The major energy-producing reactions of biochemistry occur at biological membranes.
Computational protein design now provides the opportunity to elucidate the underlying …

Engineering synthetic regulatory circuits with precise input-output behavior—a central goal
in synthetic biology—remains encumbered by the inherent molecular complexity of cells …

The design of proteins capable to effectively bind to specific protein targets is crucial for
developing therapies, diagnostics, and vaccine candidates for viral infections. Here, we …