In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use
The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …
Tight junctions of the blood–brain barrier: development, composition and regulation
H Wolburg, A Lippoldt - Vascular pharmacology, 2002 - Elsevier
1. The blood–brain barrier is essential for the maintenance and regulation of the neural
microenvironment. The main characteristic features of blood–brain barrier endothelial cells …
microenvironment. The main characteristic features of blood–brain barrier endothelial cells …
Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier
Background Gut microbiota composition and function are symbiotically linked with host
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …
A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport
NR Wevers, DG Kasi, T Gray, KJ Wilschut… - Fluids and Barriers of …, 2018 - Springer
Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …
large molecules into the brain. The aim of this study was to develop a novel model of the …
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
Epidemiological and experimental data implicate branched-chain amino acids (BCAAs) in
the development of insulin resistance, but the mechanisms that underlie this link remain …
the development of insulin resistance, but the mechanisms that underlie this link remain …
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
Aberrant neovascularization contributes to diseases such as cancer, blindness and
atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although …
atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although …
Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line
BB Weksler, EA Subileau, N Perriere… - The FASEB …, 2005 - Wiley Online Library
Establishment of a human model of the blood‐brain barrier has proven to be a difficult goal.
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …
Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats
Dementia is a major social and economic problem for our aging population. One of the most
common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic …
common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic …
Design and validation of a human brain endothelial microvessel-on-a-chip open microfluidic model enabling advanced optical imaging
We describe here the design and implementation of an in vitro microvascular open model
system using human brain microvascular endothelial cells. The design has several …
system using human brain microvascular endothelial cells. The design has several …
Permeability studies on in vitro blood–brain barrier models: physiology, pathology, and pharmacology
MA Deli, CS Ábrahám, Y Kataoka, M Niwa - Cellular and molecular …, 2005 - Springer
The specifically regulated restrictive permeability barrier to cells and molecules is the most
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …