Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Traumatic brain injury: an overview of epidemiology, pathophysiology, and medical management

A Capizzi, J Woo, M Verduzco-Gutierrez - Medical Clinics, 2020 - medical.theclinics.com
The goal of this article is to provide a general review of the epidemiology, acute care, and
chronic management of adult patients with traumatic brain injuries (TBI). This text was …

Functional outcomes over the first year after moderate to severe traumatic brain injury in the prospective, longitudinal TRACK-TBI study

MA McCrea, JT Giacino, J Barber, NR Temkin… - JAMA …, 2021 - jamanetwork.com
Importance Moderate to severe traumatic brain injury (msTBI) is a major cause of death and
disability in the US and worldwide. Few studies have enabled prospective, longitudinal …

Practice guideline update recommendations summary: disorders of consciousness: report of the Guideline Development, Dissemination, and Implementation …

JT Giacino, DI Katz, ND Schiff, J Whyte, EJ Ashman… - Neurology, 2018 - AAN Enterprises
Objective To update the 1995 American Academy of Neurology (AAN) practice parameter on
persistent vegetative state and the 2002 case definition on minimally conscious state (MCS) …

Traumatic brain injury as a chronic disease: insights from the United States traumatic brain injury model systems research program

K Dams-O'Connor, SB Juengst, J Bogner… - The Lancet …, 2023 - thelancet.com
Traumatic brain injury (TBI) is a global health priority, associated with substantial burden.
Historically conceptualised as an injury event with finite recovery, TBI is now recognised as …

Disorders of consciousness after acquired brain injury: the state of the science

JT Giacino, JJ Fins, S Laureys, ND Schiff - Nature Reviews Neurology, 2014 - nature.com
The concept of consciousness continues to defy definition and elude the grasp of
philosophical and scientific efforts to formulate a testable construct that maps to human …

Cognitive-motor dissociation and time to functional recovery in patients with acute brain injury in the USA: a prospective observational cohort study

J Egbebike, Q Shen, K Doyle… - The Lancet …, 2022 - thelancet.com
Background Recovery trajectories of clinically unresponsive patients with acute brain injury
are largely uncertain. Brain activation in the absence of a behavioural response to spoken …

Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury

RG Kowalski, FM Hammond, AH Weintraub… - JAMA …, 2021 - jamanetwork.com
Importance Traumatic brain injury (TBI) leads to 2.9 million visits to US emergency
departments annually and frequently involves a disorder of consciousness (DOC). Early …

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

AIR Maas, DK Menon, PD Adelson, N Andelic… - The Lancet …, 2017 - thelancet.com
Executive summary A concerted effort to tackle the global health problem posed by traumatic
brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently …

Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …