The β-thalassemias are a group of hereditary hematological diseases caused by over 300
mutations of the adult β-globin gene. Together with sickle cell anemia, thalassemia …

Beta-thalassemia is a group of frequent genetic disorders resulting in the synthesis of little or
no β-globin chains. Novel approaches are being developed to correct the resulting α/β …

Ineffective erythropoiesis is observed in many erythroid disorders including β‐thalassemia
and anemia of chronic disease in which increased production of erythroblasts that fail to …

Anaemia or decreased blood haemoglobin is the most common blood disorder often
characterized by reduced red blood cell (RBC) numbers. RBC s are produced from …

Circulating red blood cells (RBCs) are essential for tissue oxygenation and homeostasis.
Defective terminal erythropoiesis contributes to decreased generation of RBCs in many …

Objectives We present a standardized in vitro microfluidic assay and Occlusion Index (OI) for
the assessment of red blood cell (RBC)–mediated microcapillary occlusion and its clinical …

Background Hydroxyurea is one of the earliest drugs that showed promise in the
management of haemoglobinopathies that include β-thalassaemia and sickle cell disease …

Abstract β-thalassemias are common hemoglobinopathies due to mutations in the β-globin
gene that lead to hemolytic anemias. Premature death of β-thalassemic erythroid precursors …

FOXO are safeguards of homeostatic hematopoiesis. FOXO networks and their regulators
and coactivators in HSPC are greatly complex and less well described. Identifications and …

Cytokine release syndrome, a prominent mechanism of morbidity and mortality in patients
with coronavirus disease 2019 (COVID-19), can cause multiple bodily reactions, including …