Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Purinergic signalling, ie ATP as an extracellular signalling molecule and cotransmitter in
both peripheral and central neurons, is involved in the physiology of neurotransmission and …

Sporadic Alzheimer's disease (SAD) is a slowly progressive neurodegenerative disorder.
This study aimed to investigate neuroprotective potential of tadalafil (TAD) and bergapten …

The ability of the N-methyl-d-aspartate receptor antagonist ketamine to induce a rapid and
sustained antidepressant effect has led to a surge in pre-clinical studies investigating …

Background It has been suggested that dysregulation of γ-aminobutyric acid (GABA)-
mediated neurotransmission is involved in the etiology of major depressive disorder and in …

Discovering that the anesthetic drug ketamine has rapidly acting antidepressant effects in
many individuals with major depression is one of the most important findings in clinical …

Depressed mood, which can occur in the context of major depressive disorder, bipolar
disorder, and other conditions, represents a serious threat to public health and wellness …

The present study was conducted to evaluate the efficacy of fenofibrate and pioglitazone in a
mouse model of amyloidogenesis induced by amyloidβ (βA) peptide. Mice were injected …

Based on theoretical considerations, experimental data with cells in vitro, animal studies in
vivo, as well as a single case pilot study with one colitis patient, a consolidated hypothesis …

Transmembrane proteins play vital roles in mediating synaptic transmission, plasticity, and
homeostasis in the brain. However, these proteins, especially the G protein–coupled …