Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Normal human red blood cells have an average life span of about 120 days in the circulation
after which they are engulfed by macrophages. This is an extremely efficient process as …

Red blood cell (RBC) storage in the blood bank promotes the progressive accumulation of
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …

Transfusions can be a life-saving treatment of patients with sickle-cell disease (SCD).
However, availability of matched units can be limiting because of distinctive blood group …

Significant research has focused individually on blood donors, product preparation and
storage, and optimal transfusion practice. To better understand the interplay between these …

BACKGROUND RBC transfusion effectiveness varies due to donor, component, and
recipient factors. Prior studies identified characteristics associated with variation in …

BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the
ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs …

Abstract Background The Recipient Epidemiology and Donor Evaluation Study‐IV‐Pediatric
(REDS‐IV‐P) is a new iteration of prior National Heart, Lung, and Blood Institute (NHLBI) …

BACKGROUND Cigarette smoking is a frequent habit across blood donors (approx. 13% of
the donor population), that could compound biologic factors and exacerbate oxidant stress …

Alloimmunization against red blood cell antigens and delayed hemolytic transfusion reaction
(DHTR) are major barriers to transfusion in sickle cell disease (SCD). In SCD, DHTR is a …