Computational coherent Raman scattering imaging: breaking physical barriers by fusion of advanced instrumentation and data science
Coherent Raman scattering (CRS) microscopy is a chemical imaging modality that provides
contrast based on intrinsic biomolecular vibrations. To date, endeavors on instrumentation …
contrast based on intrinsic biomolecular vibrations. To date, endeavors on instrumentation …
Rapid single-particle chemical imaging of nanoplastics by SRS microscopy
Plastics are now omnipresent in our daily lives. The existence of microplastics (1 µm to 5 mm
in length) and possibly even nanoplastics (< 1 μm) has recently raised health concerns. In …
in length) and possibly even nanoplastics (< 1 μm) has recently raised health concerns. In …
Quantitative stimulated Raman scattering microscopy: promises and pitfalls
B Manifold, D Fu - Annual Review of Analytical Chemistry, 2022 - annualreviews.org
Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a
powerful chemical imaging tool that shows promise in numerous biological and biomedical …
powerful chemical imaging tool that shows promise in numerous biological and biomedical …
Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology
Gastroscopic biopsy provides the only effective method for gastric cancer diagnosis, but the
gold standard histopathology is time-consuming and incompatible with gastroscopy …
gold standard histopathology is time-consuming and incompatible with gastroscopy …
Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids
Fatty acids are an important source of energy and a key component of phospholipids in
membranes and organelles. Saturated fatty acids (SFAs) are converted into unsaturated fatty …
membranes and organelles. Saturated fatty acids (SFAs) are converted into unsaturated fatty …
Profiling single cancer cell metabolism via high-content SRS imaging with chemical sparsity
Metabolic reprogramming in a subpopulation of cancer cells is a hallmark of tumor
chemoresistance. However, single-cell metabolic profiling is difficult because of the lack of a …
chemoresistance. However, single-cell metabolic profiling is difficult because of the lack of a …
Single-cell mapping of lipid metabolites using an infrared probe in human-derived model systems
Understanding metabolic heterogeneity is the key to uncovering the underlying mechanisms
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …
In situ and real-time mold flux analysis using a high-temperature fiber-optic Raman sensor for steel manufacturing applications
B Zhang, H Tekle, RJ O'Malley, T Sander… - Journal of Lightwave …, 2023 - opg.optica.org
Continuous casting in steel production uses specially developed oxyfluoride glasses (mold
fluxes) to lubricate a mold and control the solidification of the steel in the mold. The …
fluxes) to lubricate a mold and control the solidification of the steel in the mold. The …
Deep learning autofluorescence-harmonic microscopy
Laser scanning microscopy has inherent tradeoffs between imaging speed, field of view
(FOV), and spatial resolution due to the limitations of sophisticated mechanical and optical …
(FOV), and spatial resolution due to the limitations of sophisticated mechanical and optical …
Multi-molecular hyperspectral PRM-SRS microscopy
Lipids play crucial roles in many biological processes. Mapping spatial distributions and
examining the metabolic dynamics of different lipid subtypes in cells and tissues are critical …
examining the metabolic dynamics of different lipid subtypes in cells and tissues are critical …