The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …

Chromatin immunoprecipitation followed by sequencing (ChIP–seq) is a technique for
genome-wide profiling of DNA-binding proteins, histone modifications or nucleosomes …

Genome-scale studies have revealed extensive, cell type-specific colocalization of
transcription factors, but the mechanisms underlying this phenomenon remain poorly …

We used genome-wide sequencing methods to study stimulus-dependent enhancer function
in mouse cortical neurons. We identified∼ 12,000 neuronal activity-regulated enhancers …

A major yet unresolved quest in decoding the human genome is the identification of the
regulatory sequences that control the spatial and temporal expression of genes. Distant …

Motivation: Chromatin states are the key to gene regulation and cell identity. Chromatin
immunoprecipitation (ChIP) coupled with high-throughput sequencing (ChIP-Seq) is …

Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear
how enhancers cooperate during these processes. Here we investigate enhancer …

In contrast to protein-coding sequences, the significance of variation in non-coding DNA in
human disease has been minimally explored. A great number of recent genome-wide …

Antiangiogenic and cytotoxic effects are considered the principal mechanisms of action of
sorafenib, a multitarget kinase inhibitor approved for the treatment of hepatocellular …

Abstract The Polycomb group (PcG) proteins are transcriptional repressors that regulate
lineage choices during development and differentiation. Recent studies have advanced our …