[HTML][HTML] A platform technology for ultra-long acting intratumoral therapy
J Henise, JA Hangasky, D Charych, CW Carreras… - Scientific Reports, 2024 - nature.com
Intratumoral (IT) therapy is a powerful method of controlling tumor growth, but a major
unsolved problem is the rapidity that injected drugs exit tumors, limiting on-target exposure …
unsolved problem is the rapidity that injected drugs exit tumors, limiting on-target exposure …
[HTML][HTML] PLX038A, a long-acting SN-38, penetrates the blood-tumor-brain-barrier, accumulates and releases SN-38 in brain tumors to increase survival of tumor …
J Jung, EL Schneider, W Zhang, H Song, M Zhang… - Scientific Reports, 2024 - nature.com
Central nervous system tumors have resisted effective chemotherapy because most
therapeutics do not penetrate the blood-tumor-brain-barrier. Nanomedicines between~ 10 …
therapeutics do not penetrate the blood-tumor-brain-barrier. Nanomedicines between~ 10 …
[HTML][HTML] Could a Long-Acting Prodrug of SN-38 be Efficacious in Sacituzumab Govitecan-Resistant Tumors?
We previously proposed that sacituzumab govitecan (SG, Trodelvy®) likely acts as a simple
prodrug of systemic SN-38 as well as an antibody drug conjugate (ADC). In the present …
prodrug of systemic SN-38 as well as an antibody drug conjugate (ADC). In the present …
Releasable hydrogel microsphere-drug conjugates as generic prodrugs for long-acting intra-tumoral therapy
J Henise, JA Hangasky, D Charych, CW Carreras… - bioRxiv, 2024 - biorxiv.org
Intratumoral (IT) therapy is a powerful method of controlling tumor growth, but a major
unsolved problem is the rapidity that injected drugs exit tumors, limiting on-target exposure …
unsolved problem is the rapidity that injected drugs exit tumors, limiting on-target exposure …
A very long-acting exatecan and its synergism with DNA damage response inhibitors
SD Fontaine, CW Carreras, RR Reid, GW Ashley… - Cancer Research …, 2023 - AACR
Exatecan (Exa) is a very potent inhibitor of topoisomerase I and anticancer agent. It has
been intensively studied as a single agent, a large macromolecular conjugate and as the …
been intensively studied as a single agent, a large macromolecular conjugate and as the …
[PDF][PDF] Ovarian Cancer Chemotherapy: Targeted Drug Conjugate Systems
OD Ogundipe, O Olajubutu, SK Adesina - 2024 - researchgate.net
This chapter discusses advances in ovarian cancer chemotherapy. Ovarian cancer is one of
the deadliest diseases that affect women worldwide. Unfortunately, most women with …
the deadliest diseases that affect women worldwide. Unfortunately, most women with …