Epitope-based vaccine design: a comprehensive overview of bioinformatics approaches

S Parvizpour, MM Pourseif, J Razmara, MA Rafi… - Drug Discovery …, 2020 - Elsevier
Highlights•Epitope vaccines provide maximal therapeutic efficacy with minimal side
effects.•Reverse vaccinology can be used for designing epitope vaccines.•Computational …

Immunoinformatics and vaccine development: an overview

AN Oli, WO Obialor, MO Ifeanyichukwu… - ImmunoTargets and …, 2020 - Taylor & Francis
The use of vaccines have resulted in a remarkable improvement in global health. It has
saved several lives, reduced treatment costs and raised the quality of animal and human …

Identification of Putative Vaccine and Drug Targets against the Methicillin-Resistant Staphylococcus aureus by Reverse Vaccinology and Subtractive Genomics …

RS Naorem, BD Pangabam, SS Bora, G Goswami… - Molecules, 2022 - mdpi.com
Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen and
responsible for causing life-threatening infections. The emergence of hypervirulent and …

Subtractive genomics profiling for potential drug targets identification against Moraxella catarrhalis

B Ashraf, N Atiq, K Khan, A Wadood, R Uddin - Plos one, 2022 - journals.plos.org
Moraxella catarrhalis (M. catarrhalis) is a gram-negative bacterium, responsible for major
respiratory tract and middle ear infection in infants and adults. The recent emergence of the …

Immunoinformatics and Molecular Docking Studies Predicted Potential Multiepitope‐Based Peptide Vaccine and Novel Compounds against Novel SARS‐CoV‐2 …

M Waqas, A Haider, A Rehman… - BioMed research …, 2021 - Wiley Online Library
Background. Coronaviruses (CoVs) are enveloped positive‐strand RNA viruses which have
club‐like spikes at the surface with a unique replication process. Coronaviruses are …

Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs against them: An in silico approach

A Sahu, M Gaur, NC Mahanandia, E Subudhi… - Computers in Biology …, 2023 - Elsevier
Monkeypox virus (mpox virus) outbreak has rapidly spread to 82 non-endemic countries.
Although it primarily causes skin lesions, secondary complications and high mortality (1 …

Elucidation of novel compounds and epitope-based peptide vaccine design against C30 endopeptidase regions of SARS-CoV-2 using immunoinformatics …

S Marriam, MS Afghan, M Nadeem, M Sajid… - Frontiers in Cellular …, 2023 - frontiersin.org
There has been progressive improvement in immunoinformatics approaches for epitope-
based peptide design. Computational-based immune-informatics approaches were applied …

Computational Design of a Chimeric Vaccine against Plesiomonas shigelloides Using Pan-Genome and Reverse Vaccinology

M Mushtaq, S Khan, M Hassan, AI Al-Harbi… - Vaccines, 2022 - mdpi.com
The swift emergence of antibiotic resistance (AR) in bacterial pathogens to make themselves
adaptable to changing environments has become an alarming health issue. To prevent AR …

Identification of a Novel Therapeutic Target against XDR Salmonella Typhi H58 Using Genomics Driven Approach Followed Up by Natural Products Virtual Screening

K Jalal, K Khan, M Hassam, MN Abbas, R Uddin… - Microorganisms, 2021 - mdpi.com
Typhoid fever is caused by a pathogenic, rod-shaped, flagellated, and Gram-negative
bacterium known as Salmonella Typhi. It features a polysaccharide capsule that acts as a …

Identification of repurposable drug targets in Mycoplasma pneumoniae using subtractive genomics, molecular docking and dynamics simulation

ZM Chowdhury, TB Jamal, I Ahammad… - Heliyon, 2023 - cell.com
Mycoplasma pneumoniae is a significant causative agent of community-acquired
pneumonia, causing acute inflammation in the upper and lower respiratory tract as well as …