Mechanisms of neuronal migration in the adult brain

N Kaneko, M Sawada… - Journal of neurochemistry, 2017 - Wiley Online Library
Adult neurogenesis was first observed nearly 60 years ago, and it has since grown into an
important neurochemistry research field. Much recent research has focused on the treatment …

Early life stress and metabolic plasticity of brain cells: impact on neurogenesis and angiogenesis

AB Salmina, YV Gorina, YK Komleva, YA Panina… - Biomedicines, 2021 - mdpi.com
Early life stress (ELS) causes long-lasting changes in brain plasticity induced by the
exposure to stress factors acting prenatally or in the early postnatal ontogenesis due to …

A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

BW Okaty, N Sturrock, Y Escobedo Lozoya, YJ Chang… - Elife, 2020 - elifesciences.org
Among the brainstem raphe nuclei, the dorsal raphe nucleus (DR) contains the greatest
number of Pet1-lineage neurons, a predominantly serotonergic group distributed throughout …

SARS-CoV-2 infection: a role for S1P/S1P receptor signaling in the nervous system?

E Meacci, M Garcia-Gil, F Pierucci - International Journal of Molecular …, 2020 - mdpi.com
The recent coronavirus disease (COVID-19) is still spreading worldwide. The severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus responsible for COVID-19 …

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration

R Belvindrah, K Natarajan, P Shabajee… - Journal of Cell …, 2017 - rupress.org
Brain development involves extensive migration of neurons. Microtubules (MTs) are key
cellular effectors of neuronal displacement that are assembled from α/β-tubulin …

Implications of extended inhibitory neuron development

JY Kim, MF Paredes - International journal of molecular sciences, 2021 - mdpi.com
A prolonged developmental timeline for GABA (γ-aminobutyric acid)-expressing inhibitory
neurons (GABAergic interneurons) is an amplified trait in larger, gyrencephalic animals. In …

Lessons from S1P receptor targeting in multiple sclerosis

E Colombo, C Farina - Pharmacology & Therapeutics, 2022 - Elsevier
Abstract Sphingosine 1-phosphate (S1P) is a potent bioactive sphingolipid binding to
specific G protein-coupled receptors expressed in several organs. The relevance of S1P …

Overlapping migratory mechanisms between neural progenitor cells and brain tumor stem cells

N Zarco, E Norton, A Quiñones-Hinojosa… - Cellular and molecular …, 2019 - Springer
Neural stem cells present in the subventricular zone (SVZ), the largest neurogenic niche of
the mammalian brain, are able to self-renew as well as generate neural progenitor cells …

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

GE Lidgerwood, SM Pitson, C Bonder, A Pébay - Progress in lipid research, 2018 - Elsevier
Stem cells are unique in their ability to self-renew and differentiate into various cell types.
Because of these features, stem cells are key to the formation of organisms and play …

[HTML][HTML] Lipid mapping of the rat brain for models of disease

J Martínez-Gardeazabal, EG de San Román… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Lipids not only constitute the primary component of cellular membranes and contribute to
metabolism but also serve as intracellular signaling molecules and bind to specific …