For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Abstract The RAS–RAF–MEK–ERK pathway is the most well-studied of the MAPK cascades
and is critical for cell proliferation, differentiation, and survival. Abnormalities in regulation …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

The identification of driver oncogenes has provided important targets for drugs that can
change the landscape of cancer therapies. One such example is the BRAF oncogene, which …

Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise
contributions to oncogenesis are still emerging. Here we report that the lncRNA MALAT1 is …

Alopecia areata (AA) is a prevalent autoimmune disease with 10 known susceptibility loci.
Here we perform the first meta-analysis of research on AA by combining data from two …

SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …

The serine/arginine-rich splicing factors (SRs) belong to the serine arginine-rich protein
family, which plays an extremely important role in the splicing process of precursor RNA …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …