The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

The mouse retina has been used extensively over the past decades to study both
physiologic and pathologic angiogenesis. Over time, various mouse retina models have …

Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …

Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

Lipid metabolic abnormalities have emerged as potential risk factors for the development
and progression of diabetic complications, including diabetic retinopathy (DR). This review …

Objective: Although cellular heterogeneity within arterial walls has been explored in mice
and nonhuman primates, the cellular composition of human arterial walls remains unclear …

Background Pericytes and endothelial cells are critical cellular components of the blood-
brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of …

Calcium phosphate cements (CPC) are currently widely used bone replacement materials
with excellent bioactivity, but have considerable disadvantages like slow degradation. For …

Cardiovascular disease is a major cause of mortality and morbidity. Current research
investigating the roles of nitric oxide (NO) with relevance to the cardiovascular system is an …