Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion
S Xue, Y Han, F Wu, Q Wang - Protein & Cell, 2024 - academic.oup.com
Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes
and results in various novel variants with distinct mutation profiles. Point mutations …
and results in various novel variants with distinct mutation profiles. Point mutations …
Allosteric signal within the receptor-binding domain of the SARS-CoV-2 spike protein mediated by a class 3 monoclonal antibody revealed through molecular …
P Boonserm, W Somsoros, P Khunrae, K Charupanit… - ACS …, 2024 - ACS Publications
This study investigated the allosteric action within the receptor-binding domain (RBD) of the
SARS-CoV-2 spike protein caused by class 3 monoclonal antibody (mAb) binding. As the …
SARS-CoV-2 spike protein caused by class 3 monoclonal antibody (mAb) binding. As the …
Evaluation of a SARS-CoV-2 spike protein ectodomain subunit vaccine with a squalene emulsion adjuvant in rodents and rhesus macaques
M Solomadin, K Tabynov, N Petrovsky… - Human Vaccines & …, 2023 - Taylor & Francis
ABSTRACT COVID-19 vaccines have played an important role in reducing the impact of the
current pandemic. Previously, we developed NARUVAX-C19 vaccine based on a …
current pandemic. Previously, we developed NARUVAX-C19 vaccine based on a …
[HTML][HTML] Genomic surveillance and vaccine response to the dominant SARS-CoV-2 XBB lineage in Rio Grande do Sul
BC Piccoli, TR y Castro, LF Tessele, BC Casarin… - Scientific Reports, 2024 - nature.com
The COVID-19 pandemic has been marked by novel viral variants, posing challenges to
global public health. Recombination, a viral evolution mechanism, is implicated in SARS …
global public health. Recombination, a viral evolution mechanism, is implicated in SARS …
A universal recombinant adenovirus type 5 vector-based COVID-19 vaccine
X Li, Q Peng, X Liu, H Xu, J Liu, X Wu, Q Ye… - Frontiers in …, 2024 - frontiersin.org
A universal recombinant adenovirus type-5 (Ad5) vaccine against COVID19 (Ad-US) was
constructed, and immunogenicity and broad-spectrum of Ad5-US were evaluated with both …
constructed, and immunogenicity and broad-spectrum of Ad5-US were evaluated with both …
Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae
By largely unknown mechanism (s), SARS-CoV-2 hijacks the host translation apparatus to
promote COVID-19 pathogenesis. We report that the histone methyltransferase G9a …
promote COVID-19 pathogenesis. We report that the histone methyltransferase G9a …
Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection system
S Taminishi, S Li, Y Higuchi, Y Kirita, D Motooka… - bioRxiv, 2023 - biorxiv.org
In order to investigate SARS-CoV-2 mutations and their impact on immune evasion and
infectivity, we developed a Deep Mutational Scanning (DMS) platform utilizing an inverted …
infectivity, we developed a Deep Mutational Scanning (DMS) platform utilizing an inverted …
Predominance of the recombinant SARS-CoV-2 lineages XBB in Rio Grande do Sul State, Brazil: a genomic surveillance study and impact on vaccine response
BC Piccoli, TR y Castro, LF Tessele, BC Casarin… - 2024 - researchsquare.com
Purpose The COVID-19 pandemic has been marked by novel viral variants, posing
challenges to global public health. Recombination, a viral evolution tool, is implicated in …
challenges to global public health. Recombination, a viral evolution tool, is implicated in …
Non-Canonical Translation Regulatory Function of G9a in Chronic Inflammation Associated Diseases
A Muneer - 2023 - search.proquest.com
We report a novel translation-regulatory function of G9a, a histone methyltransferase and
well-understood transcriptional repressor, in promoting hyperinflammation and …
well-understood transcriptional repressor, in promoting hyperinflammation and …
Evolutionary Constraints and Potential of the Influenza A Virus RNA-dependent RNA Polymerase
Y Li - 2024 - search.proquest.com
Due to rapid evolution and adaptation, influenza viruses remain a major health concern
despite co-existing with human beings for centuries. The influenza virus polymerase is a …
despite co-existing with human beings for centuries. The influenza virus polymerase is a …