Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory
drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in …

Melatonin, along with its metabolites, have long been known to significantly reduce the
oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …

DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the
DNA repair pathways have been identified in several human cancers. Thus, compounds …

Melatonin (N‐acetyl‐5‐hydroxytryptamine) is a pineal hormone widely known for its
antioxidant properties, both in vivo and by direct capture of free radicals in vitro. Although …

Objective To provide a summary of knowledge about the use of melatonin in the treatment of
primary headache disorders. Background Melatonin is secreted by the pineal gland; its …

Many exogenous (eg, toxins, chemicals, ultraviolet, cigarette smoke) and endogenous (eg,
hyperglycemia, dyslipidemia, cytokines, chemokines) agents disrupt the intracellular …

Topiramate is an anticonvulsant drug effective against a wide range of seizures and
epilepsies. The present study was conducted to investigate the possible protective effect of …

Aging leads to a high burden on society, both medically and economically. Cellular
senescence plays an essential role in the initiation of aging and age-related diseases …