Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Alzheimer's disease (AD) is an incredibly complex and presently incurable age-related brain
disorder. To better understand this debilitating disease, we collated and performed a meta …

To better understand DNA methylation in Alzheimer's disease (AD) from both mechanistic
and biomarker perspectives, we performed an epigenome-wide meta-analysis of blood DNA …

Alzheimer's disease (AD) is the most common neurodegenerative disease and the most
common cause of dementia. Among various pathophysiological aspects, microglia are …

Quantifying biological aging is critical for understanding why aging is the primary driver of
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …

Sex is an important factor that contributes to the clinical and biological heterogeneities in
Alzheimer's disease (AD), but the regulatory mechanisms underlying sex disparity in AD are …

Neurodegenerative diseases encompass a heterogeneous group of conditions
characterised by the progressive degeneration of the structure and function of the central or …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are closely related
progressive disorders with no available disease-modifying therapy, neuropathologically …