Epidermolysis bullosa (EB) is a highly diverse group of inherited skin disorders, resulting
from mutations in genes encoding proteins of the dermoepidermal junction. Itch (pruritus) is …

Gene therapy serves as a promising therapy in the pipeline for treatment of epidermolysis
bullosa (EB). However, with great promise, the risk of autoimmunity must be considered …

Background Historically, diagnosis of epidermolysis bullosa has required skin biopsies for
electron microscopy, direct immunofluorescence to determine which gene (s) to choose for …

Junctional epidermolysis bullosa (JEB) is a rare, incurable, devastating, and mostly fatal
congenital genetic disorder characterized by painful blistering of the skin and mucous …

Mutations in ITGB4 are known to cause autosomal recessive junctional epidermolysis
bullosa (JEB), which is manifested by severe blistering and granulation tissue, usually …

BACKGROUND: Inherited epidermolysis bullosa is a severe orphan hereditary disease with
a predominant lesion of the skin and mucous membranes. The study of the comorbid …

In many glomerulopathies, there is ongoing debate as to the level of contribution of defects
in the various compartments of the glomerular filtration barrier [9, 11, 13, 150-154]. It is now …