Calcium influx in nonexcitable cells regulates such diverse processes as exocytosis,
contraction, enzyme control, gene regulation, cell proliferation, and apoptosis. The dominant …

The orderly sequence of events that constitutes the cell cycle is carefully regulated. A part of
this regulation depends upon the ubiquitous calcium signalling system. Many growth factors …

In many vertebrate and invertebrate cells, inositol 1, 4, 5-trisphospate production induces a
biphasic Ca2+ signal. Mobilization of Ca2+ from internal stores drives the initial burst. The …

Agonist-induced Ca 2+ entry into cells by both store-operated channels and channels
activated independently of Ca 2+-store depletion has been described in various cell types …

Mitochondria act as potent buffers of intracellular Ca2+ in many cells, but a more active role
in modulating the generation of Ca2+ signals is not well established. We have investigated …

The original idea that calcium might enter cells through a capacitative mechanism was first
introduced by Jim Putney [1]. The somewhat surprising hypothesis was that calcium entry …

Ca 2+ entry through store-operated Ca 2+ release-activated Ca 2+(CRAC) channels is
essential for T-cell activation and proliferation. Recently, it has been shown that 3, 5 …

Depletion of intracellular calcium stores generates a signal that activates Ca 2+-permeable
channels in the plasma membrane. We have identified a human cDNA, TRPC1A, from a …

Ca 2+ flux across the inner mitochondrial membrane (IMM) regulates cellular bioenergetics,
intra-cellular cytoplasmic Ca 2+ signals, and various cell death pathways. Ca 2+ entry into …

The widely distributed and highly conserved Ca 2+-binding protein calreticulin has been
suggested to play a role as a Ca 2+ storage protein of intracellular Ca 2+ stores. To test this …