To study complex biological processes holistically, it is imperative to take an integrative
approach that combines multi-omics data to highlight the interrelationships of the involved …

Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage,
HBV-associated HCCs. Here we present an integrated proteogenomic analysis of HCCs …

Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …

We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …

Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …

To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma
(ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic …

Current healthcare practices are reactive and use limited physiological and clinical
information, often collected months or years apart. Moreover, the discovery and profiling of …

Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due
to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker …

Many gene products exhibit great structural heterogeneity because of an array of
modifications. These modifications are not directly encoded in the genomic template but …

Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal
tumor immunity via different mechanisms of actions (MOAs), particularly various tumor …