Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

Organoids—Preclinical Models of Disease An organoid is a three-dimensional construct
composed of multiple cell types that originates from stem cells through self-organization and …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Recent progress in our understanding of the regulation of epithelial tissue stem cells has
allowed us to exploit their abilities and instruct them to self-organize into tissue-mimicking …

Glandular epithelia, including the mammary and prostate glands, are composed of basal
cells (BCs) and luminal cells (LCs),. Many glandular epithelia develop from multipotent …

Epidermal growth factor (EGF) maintains intestinal stem cell (ISC) proliferation and is a key
component of organoid growth media yet is dispensable for intestinal homeostasis …

The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

Abstract 3D culture has allowed the initiation and expansion of organ-like structures, called
organoids, from either tissue-resident adult stem cells or pluripotent stem cells. Today …

Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …