The nicotinic acetylcholine receptor has served, since its biochemical identification in the
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …

Receptors signal by switching between resting (C) and active (O) shapes ('gating') under the
influence of agonists. The receptor's maximum response depends on the difference in …

How do agonists turn on receptors? The model system we have used to address this
question is the adult-type skeletal muscle nicotinic acetylcholine receptor. This ligand-gated …

Glycine receptors (GlyRs) regulate motor control and pain processing in the central nervous
system through inhibitory synaptic signaling. The subtype GlyRα3 expressed in nociceptive …

Glycine receptors (GlyR) conduct inhibitory glycinergic neurotransmission in the spinal cord
and the brainstem. They play an important role in muscle tone, motor coordination …

Understanding the agonist concentration-response curve (CRC) is the cornerstone in
pharmacology. While CRC parameters, agonist potency (EC 50) and efficacy (maximum …

The serotonin-gated ion channel (5-HT 3 R) mediates excitatory neuronal communication in
the gut and the brain. It is the target for setrons, a class of competitive antagonists widely …

变构蛋白是一类具有特殊变构效应的蛋白质, 其变构动态调节的多样性大大丰富了蛋白质的活性
或特异性. 探究蛋白变构效应及其调控机制, 在拓展蛋白功能, 药物研发和信号传递等方面具有 …

Rapid communication at synapses is facilitated by postsynaptic receptors, which convert a
chemical signal into an electrical response. In the case of ligand-gated ion channels, agonist …

To gain insights into the binding mechanism of glycine receptors, a range of approaches can
be employed including the utilisation of classical molecular dynamics and metadynamics …