Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

N Li, Q He, J Wang, B Wang, J Zhao, S Huang… - Nature Genetics, 2023 - nature.com
Effective utilization of wild relatives is key to overcoming challenges in genetic improvement
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …

Graph pangenome captures missing heritability and empowers tomato breeding

Y Zhou, Z Zhang, Z Bao, H Li, Y Lyu, Y Zan, Y Wu… - Nature, 2022 - nature.com
Missing heritability in genome-wide association studies defines a major problem in genetic
analyses of complex biological traits,. The solution to this problem is to identify all causal …

Automated assembly scaffolding using RagTag elevates a new tomato system for high-throughput genome editing

M Alonge, L Lebeigle, M Kirsche, K Jenike, S Ou… - Genome biology, 2022 - Springer
Advancing crop genomics requires efficient genetic systems enabled by high-quality
personalized genome assemblies. Here, we introduce RagTag, a toolset for automating …

Genomics and marker-assisted improvement of vegetable crops

I Simko, M Jia, J Venkatesh, BC Kang… - Critical Reviews in …, 2021 - Taylor & Francis
Vegetables are an integral part of the human diet worldwide. Traditional breeding
approaches have been used extensively to develop new cultivars of vegetables with …

An efficient CRISPR–Cas12a promoter editing system for crop improvement

J Zhou, G Liu, Y Zhao, R Zhang, X Tang, L Li, X Jia… - Nature Plants, 2023 - nature.com
Promoter editing represents an innovative approach to introduce quantitative trait variation
(QTV) in crops. However, an efficient promoter editing system for QTV needs to be …

The genetic and epigenetic landscape of the Arabidopsis centromeres

M Naish, M Alonge, P Wlodzimierz, AJ Tock… - Science, 2021 - science.org
INTRODUCTION The centromeres of eukaryotic chromosomes assemble the multiprotein
kinetochore complex and thereby position attachment to the spindle microtubules, allowing …

Major impacts of widespread structural variation on gene expression and crop improvement in tomato

M Alonge, X Wang, M Benoit, S Soyk, L Pereira… - Cell, 2020 - cell.com
Structural variants (SVs) underlie important crop improvement and domestication traits.
However, resolving the extent, diversity, and quantitative impact of SVs has been …

Two divergent haplotypes from a highly heterozygous lychee genome suggest independent domestication events for early and late-maturing cultivars

G Hu, J Feng, X Xiang, J Wang, J Salojärvi, C Liu… - Nature …, 2022 - nature.com
Lychee is an exotic tropical fruit with a distinct flavor. The genome of cultivar 'Feizixiao'was
assembled into 15 pseudochromosomes, totaling~ 470 Mb. High heterozygosity (2.27%) …

Vegetable biology and breeding in the genomics era

H Li, X Yang, Y Shang, Z Zhang, S Huang - Science China Life Sciences, 2023 - Springer
Vegetable crops provide a rich source of essential nutrients for humanity and represent
critical economic values to global rural societies. However, genetic studies of vegetable …

Phased, chromosome-scale genome assemblies of tetraploid potato reveal a complex genome, transcriptome, and predicted proteome landscape underpinning …

G Hoopes, X Meng, JP Hamilton, SR Achakkagari… - Molecular plant, 2022 - cell.com
Cultivated potato is a clonally propagated autotetraploid species with a highly
heterogeneous genome. Phased assemblies of six cultivars including two chromosome …