Tracing the footsteps of autophagy in computational biology
Autophagy plays a crucial role in maintaining cellular homeostasis through the degradation
of unwanted materials like damaged mitochondria and misfolded proteins. However, the …
of unwanted materials like damaged mitochondria and misfolded proteins. However, the …
Unbiased identification of blood-based biomarkers for pulmonary tuberculosis by modeling and mining molecular interaction networks
Efficient diagnosis of tuberculosis (TB) is met with multiple challenges, calling for a shift of
focus from pathogen-centric diagnostics towards identification of host-based multi-marker …
focus from pathogen-centric diagnostics towards identification of host-based multi-marker …
Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that
mediates resistance to one of the highly effective antibacterials, β-lactams. Nonetheless, β …
mediates resistance to one of the highly effective antibacterials, β-lactams. Nonetheless, β …
VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis
The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an
unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M …
unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M …
Meta-analysis of host response networks identifies a common core in tuberculosis
Tuberculosis remains a major global health challenge worldwide, causing more than a
million deaths annually. To determine newer methods for detecting and combating the …
million deaths annually. To determine newer methods for detecting and combating the …
A path-based analysis of infected cell line and COVID-19 patient transcriptome reveals novel potential targets and drugs against SARS-CoV-2
Most transcriptomic studies of SARS-CoV-2 infection have focused on differentially
expressed genes, which do not necessarily reveal the genes mediating the transcriptomic …
expressed genes, which do not necessarily reveal the genes mediating the transcriptomic …
Immune subtyping in latent tuberculosis
Latent tuberculosis infection (LTBI) poses a major roadblock in the global effort to eradicate
tuberculosis (TB). A deep understanding of the host responses involved in establishment …
tuberculosis (TB). A deep understanding of the host responses involved in establishment …
PathTracer Comprehensively Identifies Hypoxia-Induced Dormancy Adaptations in Mycobacterium tuberculosis
U Banerjee, A Chedere, R Padaki… - Journal of Chemical …, 2023 - ACS Publications
Mining large-scale data to discover biologically relevant information remains a challenge
despite the rapid development of bioinformatics tools. Here, we have developed a new tool …
despite the rapid development of bioinformatics tools. Here, we have developed a new tool …
PathExt: a general framework for path-based mining of omics-integrated biological networks
Motivation Transcriptomes are routinely used to prioritize genes underlying specific
phenotypes. Current approaches largely focus on differentially expressed genes (DEGs) …
phenotypes. Current approaches largely focus on differentially expressed genes (DEGs) …
A new blood-based RNA signature (R9), for monitoring effectiveness of tuberculosis treatment in a South Indian longitudinal cohort
Tuberculosis (TB) treatment involves a multidrug regimen for six months, and until two
months, it is unclear if treatment is effective. This delay can lead to the evolution of drug …
months, it is unclear if treatment is effective. This delay can lead to the evolution of drug …