Improving human cancer therapy through the evaluation of pet dogs

AK LeBlanc, CN Mazcko - Nature Reviews Cancer, 2020 - nature.com
Comparative oncology clinical trials play an important and growing role in cancer research
and drug development efforts. These trials, typically conducted in companion (pet) dogs …

Comparative oncology: overcoming human cancer through companion animal studies

JH Oh, JY Cho - Experimental & Molecular Medicine, 2023 - nature.com
Comparative oncology is a field of study that has been recently adopted for studying cancer
and developing cancer therapies. Companion animals such as dogs can be used to …

Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics

L Rodrigues, J Watson, Y Feng, B Lewis, G Harvey… - Scientific Reports, 2023 - nature.com
Naturally occurring canine cancers have remarkable similarities to their human counterparts.
To better understand these similarities, we investigated 671 client-owned dogs from 96 …

Spontaneous and induced animal models for cancer research

A Onaciu, R Munteanu, VC Munteanu, D Gulei… - Diagnostics, 2020 - mdpi.com
Considering the complexity of the current framework in oncology, the relevance of animal
models in biomedical research is critical in light of the capacity to produce valuable data with …

Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogs

K Wu, L Rodrigues, G Post, G Harvey, M White… - NPJ Precision …, 2023 - nature.com
Spontaneous tumors in canines share significant genetic and histological similarities with
human tumors, positioning them as valuable models to guide drug development. However …

Companion animals in comparative oncology: One Medicine in action

OA Garden, SW Volk, NJ Mason, JA Perry - The Veterinary Journal, 2018 - Elsevier
Comparative oncology is poised to have a far-reaching impact on both animals and human
beings with cancer. The field is gaining momentum and has repeatedly proven its utility in …

The genetic and molecular basis for canine models of human leukemia and lymphoma

AC Avery - Frontiers in oncology, 2020 - frontiersin.org
Emerging details of the gene expression and mutational features of canine lymphoma and
leukemia demonstrate areas of similarities and differences between disease subsets in the …

Horizons in veterinary precision oncology: fundamentals of cancer genomics and applications of liquid biopsy for the detection, characterization, and management of …

J Chibuk, A Flory, KM Kruglyak, N Leibman… - Frontiers in Veterinary …, 2021 - frontiersin.org
Cancer is the leading cause of death in dogs, in part because many cases are identified at
an advanced stage when clinical signs have developed, and prognosis is poor. Increased …

The K9 lymphoma assay allows a genetic subgrouping of canine lymphomas with improved risk classification

A Fanelli, L Licenziato, E Mazzone, S Divari… - Scientific Reports, 2024 - nature.com
We present here the K9 lymphoma assay, a novel 31-gene targeted next-generation
sequencing panel designed for genomic profiling of canine lymphoid neoplasms …

Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis

S Hussain, S Saxena, S Shrivastava, AK Mohanty… - PLoS …, 2018 - journals.plos.org
Spontaneously occurring canine mammary tumours (CMTs) are the most common
neoplasms of unspayed female dogs leading to thrice higher mortality rates than human …