Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation
M Chehelgerdi, M Chehelgerdi, OQB Allela… - Molecular cancer, 2023 - Springer
The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …
cancer. Developments in protein engineering and materials science have led to the …
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, B Zhang… - Molecular cancer, 2021 - Springer
Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …
phenotypic and functional heterogeneity, are the most essential components of the tumor …
Kinase drug discovery 20 years after imatinib: progress and future directions
Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or
mutations in their genes, cause cancer and other diseases. Here, we review the remarkable …
mutations in their genes, cause cancer and other diseases. Here, we review the remarkable …
Targeting the RNA m6A modification for cancer immunotherapy
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …
and its dysregulation drives aberrant transcription and translation programs that promote …
Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials
H Zhang, X Yue, Z Chen, C Liu, W Wu, N Zhang, Z Liu… - Molecular Cancer, 2023 - Springer
Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …
In response to precision medicine: Current subcellular targeting strategies for cancer therapy
Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …
increasing attention, bringing great opportunities for clinical application. Here, two targeting …
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression
E Yang, X Wang, Z Gong, M Yu, H Wu… - Signal transduction and …, 2020 - nature.com
Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …
[HTML][HTML] Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …
[HTML][HTML] Staging and grading of oral squamous cell carcinoma: An update
A Almangush, AA Mäkitie, A Triantafyllou, R de Bree… - Oral oncology, 2020 - Elsevier
Oral squamous cell carcinoma (OSCC) is a common malignancy of the head and neck
region. OSCC has a relatively low survival rate and the incidence of the disease is …
region. OSCC has a relatively low survival rate and the incidence of the disease is …
Nano-based approved pharmaceuticals for cancer treatment: present and future challenges
F Rodríguez, P Caruana, N De la Fuente, P Español… - Biomolecules, 2022 - mdpi.com
Cancer is one of the main causes of death worldwide. To date, and despite the advances in
conventional treatment options, therapy in cancer is still far from optimal due to the non …
conventional treatment options, therapy in cancer is still far from optimal due to the non …