Gastrointestinal (GI) motility is regulated in part by electrophysiological events called slow
waves, which are generated by the interstitial cells of Cajal (ICC). Slow waves propagate by …

Modern biology and biomedicine are undergoing a big data explosion, needing advanced
computational algorithms to extract mechanistic insights on the physiological state of living …

Food transport through different sections of the gastrointestinal tract for the purposes of
digestion and waste removal is an essential physiological function for life. Mechanical and …

Nearly all pharmaceuticals and nutrients must cross numerous barriers to gain access and
be eliminated from the body. The gastrointestinal mucosa, comprised of specialized …

Background Bioelectrical slow waves are a coordinating mechanism of small intestine
motility, but extracellular human studies have been restricted to a limited number of sparse …

Peristaltic flow is important in many biological processes, including digestion, and forms an
important component of any in silico model of the stomach. There is a clear need to verify the …

Abstract Background and Purpose The efficacy of conventional treatments for severe and
chronic functional motility disorders remains limited. High‐energy pacing is a promising …

Society is becoming increasingly critical of animal husbandry due to its environmental
impact and issues involving animal health and welfare including scientific experiments …

In recent years, the development and implementation of animal-free approaches to chemical
and pharmaceutical hazard and risk assessment has taken off. Alternative approaches are …

The aim of this study was to develop a numerical model for simulating fluid flow,
carbohydrate digestion, and glucose absorption in human small intestine. COMSOL …