Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of
preclinical research in cancer biology. The initial aim of the project was to repeat 193 …

Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

Liquid biopsy in cancer has gained momentum in clinical research and is experiencing a
boom for a variety of applications. There are significant efforts to utilize liquid biopsies in …

The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …

Metastasis is the main cause of death in people with cancer. To colonize distant organs,
circulating tumour cells must overcome many obstacles through mechanisms that we are …