Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

Dark days for diabetic patients were transformed into an era of hope when the therapeutic
usage of insulin was discovered. However, those initial glory days changed to being …

Disease-associated progression of protein dysfunction is typically determined by an
interplay of transition pathways leading to liquid–liquid phase separation (LLPS) and …

Many cellular coassemblies of proteins and polynucleotides facilitate liquid–liquid phase
separation (LLPS) and the subsequent self-assembly of disease-associated amyloid fibrils …

Insulin aggregation poses a significant problem in pharmacology and medicine as it occurs
during prolonged storage of the hormone and in vivo at insulin injection sites. We have …

Natural polyphenols, curcumin, rottlerin and EGCG were selected for initial computational
modeling of protein-ligand interaction patterns. The docking calculations demonstrated that …

Various plant species have long been used in traditional medicine worldwide to treat
diabetes. Among the plant-based compounds with hypoglycemic properties, studies on …

ATP acts as a biological hydrotrope preventing protein aggregation. Here, we report a novel
chimeric peptide, ACC1–13K8, with an unusual capacity to bind and incorporate ATP while …

Atomic force microscopy, Thioflavin T (ThT) fluorescence assay, circular dichroism
spectroscopy, differential scanning calorimetry, and molecular modeling techniques have …

Surface functionality of nanoparticles has been pivotal in defining interactions of
nanoparticles and biomolecules. To explore various functionalities on the surface of …