Cellular senescence is a state of stable proliferation arrest of cells. The senescence pathway
has many beneficial effects and is seen to be activated in damaged/stressed cells, as well as …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Introduction Recent evidence suggests that tissue accumulation of senescent p16 INK4a-
positive cells during the life span would be deleterious for tissue functions and could be the …

Objectives Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have
demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid …

Histone deacetylases (Hdacs) are conserved enzymes that remove acetyl groups from
lysine side chains in histones and other proteins. Eleven of the 18 Hdacs encoded by the …

Abstract Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-
specific gene expression in human chondrocytes. The aim of this study was to determine …

Introduction Osteoarthritis (OA) is a common joint disease that can cause gradual disability
among the aging population. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key …