Migraine is a strongly disabling disease characterized by a unilateral throbbing headache
lasting for up to 72 h for each individual attack. There have been many theories on the …

Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

Abstract Tetanus (TeNT) and botulinum (BoNT) neurotoxins, the causative agents of tetanus
and botulism, respectively, are the most potent toxic molecules known to mankind. This …

Botulinum neurotoxins (BoNTs) are potent inhibitors of synaptic vesicle fusion and
transmitter release. The natural target of BoNTs is the peripheral neuromuscular junction …

Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease.
We tested whether this parameter and tactile allodynia, the standard pain measure in …

Introduction: Migraine is a very frequent and disabling neurological disorder. The current
treatment options are old, generally poorly tolerated and not migraine-specific, reflecting the …

Most pathological pain conditions in patients and rodent pain models result in marked
alterations in mechanosensation and the gold standard way to measure this is by use of von …

Botulinum neurotoxin serotype A (BoNT/A) shows antinociceptive properties, and its clinical
applications in pain therapy are continuously increasing. BoNT/A specifically cleaves SNAP …

Chronic pain affects one in five people across human societies, with few therapeutic options
available. Botulinum neurotoxin (BoNT) can provide long-lasting pain relief by inhibiting …

Botulinum neurotoxins (BoNTs) are highly potent toxins responsible for a severe disease,
called botulism. They are also efficient therapeutic tools with an increasing number of …