Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula
L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …
systems biology theory, biological system network analysis, and multi-target drug molecule …
The functional universe of membrane contact sites
WA Prinz, A Toulmay, T Balla - Nature reviews Molecular cell biology, 2020 - nature.com
Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …
environmental and developmental changes. One way in which organelles communicate and …
[HTML][HTML] The functional impact of mitochondrial structure across subcellular scales
Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …
mitochondria varies from cell to cell depending on the relative demands for energy …
Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death
The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …
as they intimately communicate, forming very dynamic platforms termed mitochondria …
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome
MJ Barrera, S Aguilera, I Castro, P Carvajal, D Jara… - Autoimmunity …, 2021 - Elsevier
Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …
inflammation, but few studies address the contribution of mitochondria and mitochondria …
Mediation of oxidative stress toxicity induced by pyrethroid pesticides in fish
Organophosphate and organochlorine pesticides are banned in most countries because
they cause high toxicity and bioaccumulation in non-target organisms. Pyrethroid pesticides …
they cause high toxicity and bioaccumulation in non-target organisms. Pyrethroid pesticides …
Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses
A Carreras-Sureda, P Pihán, C Hetz - Cell calcium, 2018 - Elsevier
Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated
cellular processes. The ER calcium content is tightly regulated as it allows a favorable …
cellular processes. The ER calcium content is tightly regulated as it allows a favorable …
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
Endoplasmic reticulum stress is emerging as an important modulator of different pathologies
and as a mechanism contributing to cancer cell death in response to therapeutic agents. In …
and as a mechanism contributing to cancer cell death in response to therapeutic agents. In …
Increased ER–mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive
unfolded protein response (UPR), but that beyond a certain degree of ER damage, this …
unfolded protein response (UPR), but that beyond a certain degree of ER damage, this …
Mfn2 modulates the UPR and mitochondrial function via repression of PERK
JP Muñoz, S Ivanova, J Sánchez‐Wandelmer… - The EMBO …, 2013 - embopress.org
Mitofusin 2 (Mfn2) is a key protein in mitochondrial fusion and it participates in the bridging
of mitochondria to the endoplasmic reticulum (ER). Recent data indicate that Mfn2 ablation …
of mitochondria to the endoplasmic reticulum (ER). Recent data indicate that Mfn2 ablation …