Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2
cytokines are modulators of ulcerative colitis. This concept has been challenged by the …

Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease that can
involve any part of the gastrointestinal tract. It includes two main disorders: Crohn's disease …

Background Interleukin (IL)-17F, produced in IL-23R-expressing Th17 cells, is a novel
member of the IL-17 cytokine family. Given the association of IL23R with inflammatory bowel …

From epidemiological data, based on concordance data in family studies, via linkage
analysis to genome-wide association studies, we and others have accumulated robust …

Genetic variations in the autophagic pathway influence genetic predispositions to Crohn
disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic …

Crohn's disease is widely regarded as a multifactorial disease, and evidence from human
and animal studies suggests that bacteria have an instrumental role in its pathogenesis …

Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory
bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations …

Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory disorder, is
caused by a dysregulated and aberrant immune response to exposed environmental factors …

Few genetic polymorphisms predict early response to anti-TNF drugs in inflammatory bowel
disease (IBD), and even fewer have been identified in the pediatric population. However, it …

The host response against diverse bacterial pathogens involves activation of specialized
immune cells and elaboration of pro-inflammatory cytokines that help to coordinate …